Vinyl-halide-with-sodium-amide, intramolecular nucleophilic substitution of the c−br bond of (e)- and (z)-2-bromobut-2-enylamines by the pendant nitrogen atom leads to 2-ethyleneaziridines by way of stereochemical inversion at the vinylic carbon atom. the stereochemistry of the products is unambiguously established by x-ray crystallography performed on two derivatives. these cyclizations represent some of the first .... A general and efficient copper-catalyzed method for the amidation of vinyl bromides and iodides has been developed. this protocol uses a combination of 5 mol % copper iodide and 20 mol % n,n‘-dimethyl ethylenediamine. substrates bearing ester, silyl ether, and amino groups were successfully coupled under the reaction conditions. the double bond geometry of the vinyl halides was retained ..., sodium amide, commonly called sodamide (systematic name sodium azanide), is the inorganic compound with the formula nanh2. it is a salt composed of the sodium cation and the azanide anion. this solid, which is dangerously reactive toward water, is white, but commercial samples are typically gray due.

C 6 h 18 nnasi 2 : molar mass: 183.37 g/mol appearance off-white solid density: 0.9 g/cm 3, solid : melting point: 171 to 175 °c (340 to 347 °f; 444 to 448 k) boiling point, literature references. useful sterically hindered base (nahmds) for, e.g. generation of enolates, wittig reagents or carbenes. used as a base for the preparation of ester enolates: j. am. chem. soc., 93, 4945 (1971).has been found to be superior to lda for preparation of (z)-enolates of ketones under thermodynamic control: tetrahedron lett., 30, 2779 (1989)..

First step hx is easy forms vinyl halide second step removal of hx from the from che 201 at suny buffalo state college, amide synthesis. acid chlorides react with "ammonia, 1 o amines and 2 o amines" to form amides as shown in the reaction below.. the reaction requires 1 equivalent of the "ammonia/1 o or 2 o amine" with a proton scavenger (aka base) like pyridine or two equivalents of "ammonia/1 o or 2 o amine". the additional equivalent the nucleophile or base is needed to maintain the nucleophilic character ....

Preparation of alkynes from alkenes. lastly, we will briefly look at how to prepare alkynes from alkenes.this is a simple process using first halogenation of the alkene bond to form the dihaloalkane, and next, using the double elimination process to protonate the alkane and from the 2 $$\pi$$ bonds.. this first process is gone over in much greater detail in the page on halogenation of an alkene., terminal alkynes can be deprotonated with sodium amide, $\mathrm{nanh_2}$. alkyl halides can be deprotonated in e2 reactions with hot solutions of sodium hydroxide, or with cold sodium amide. since hydroxide is a weaker base than amide,....

Reactions of alkyl halides with reducing metals. the alkali metals (li, na, k etc.) and the alkaline earth metals (mg and ca, together with zn) are good reducing agents, the former being stronger than the latter.